Another study revealed that sesamol (5–20 μM) significantly inhibits the expression of several matrix metalloproteinases (MMPs), TNFα- and IL-1β-induced gelatinolysis of MMP-9, MMP-1, and MMP-13 expression, IL-1β- and phosphorylation of ERK1/2 or p38 MAPKs in SW1353 cells, a human chondrosarcoma cell line [54]. The gene discussed is TNF; the disease is chondrosarcoma.