Our study is the first to discover the role of THP in inhibiting the activation of ER stress and the NLRP3 inflammasome in HLP, as evidenced by the reduced expression of CHOP, caspase 12, GRP78, NLRP3, ASC, pro-IL-1β, and IL-1β. The gene discussed is NLRP3; the disease is hyperkeratosis lenticularis perstans.