However, the protein levels of TLR4, MyD88, and p-P65 were significantly decreased by THP treatment (HD and MD groups) or atorvastatin treatment (PC group) compared to the M group, indicating that THP could regulate HLP induced by a high-fat diet in golden hamsters by suppressing TLR4-NF-κB signaling. Here, MYD88 is linked to hyperkeratosis lenticularis perstans.