Through whole-exome sequencing, Zhang et al. [4, 5] revealed the full genomic mutational profiles of EMPD, demonstrating that KMT2C, ARID2, and FOXA1 mutations were frequent in EMPD, and other driver gene mutations, such as those in PIK3CA, KRAS, BRAF, and AKT1, have also been reported [6]. This evidence concerns the gene KRAS and extramammary Paget disease.