In addition, survival analysis of NHE family from GEPIA2 showed that high expressions of SLC9A1, SLC9A2, SLC9A3, SLC9A4, and SLC9A8 could improve the prognosis of COAD patients and low expressions of SLC9A5 and SLC9A9 could improve the prognosis of COAD patients. The gene discussed is SLC9A5; the disease is colon adenocarcinoma.