The results from TCGA and GEPIA2 showed that the mRNA expressions of SLC9A1, SLC9A2, SLC9A3, and SLC9A9 were evidently lower in COAD compared to normal samples; however, the mRNA expressions of SLC9A5, SLC9A8, and SLC9B2 were higher. The gene discussed is SLC9A8; the disease is colon adenocarcinoma.