The GM13-up related to interleukin-26 (IL26, PIK3R5, and LRRC2) was much higher expressed in severe individuals while the GM12-down module related to the nervous system (10%, p = 1.77E-04, i.e., TUBB2B, SPOCK1, and ASCL1) was much lower expressed in severe asthma individuals. This evidence concerns the gene PIK3R5 and asthma.