First, given that the physiological expression of CDX2 is limited to the gut epithelium in adults and that it is reduced in colon cancers with bad prognosis (Balbinot et al., 2018), we compared the transcriptomes in the deciles of tumors exhibiting the lowest vs highest CDX2 levels (n = 44 each) among The Cancer Genome Atlas (TCGA) collection of 436 colon adenocarcinomas (COAD). Here, CDX2 is linked to malignant colon neoplasm.