In the esophagus, retrieving the list of differentially expressed genes between healthy CDX2-free mucosa (n = 17) and CDX2-expressing non-dysplastic Barrett metaplasia (ESOBA-nd) (n = 14), low-grade dysplastic Barrett metaplasia (ESOBA-lgd) (n = 8) and adenocarcinoma (ESOAD) (n = 12) (Maag et al., 2017) revealed respectively 123, 118 and 116 orthologues of the core set of DEGs (respective enrichment p-values are 0.16 E−73, 0.21 E−64 and 0.96 E−44) (Figures 4B,C; Supplementary Table S4.4–6). The gene discussed is CDX2; the disease is adenocarcinoma.