P62/SQSTM1, a characteristic substrate of ubiquitin-protein in autophagy, which is more significantly up-regulated in GC specimens than in normal gastric mucosa (Kim et al., 2019), while the interpretation of P62/SQSTM1 has some adverse clinical outcomes of the ailment (Masuda et al., 2016). This evidence concerns the gene SQSTM1 and gastric cancer.