In recent years, an increasing number of studies have also confirmed that GBPs are not only involved in regulating host immune defense but also closely related to tumor development and metastasis (Mustafa et al., 2018; Zhao et al., 2019; Yu et al., 2020), and some GBPs, such as GBP1 and GBP2, have shown good prognostic value in certain tumors, for example, breast, oral and colorectal cancer (Yu et al., 2011; Godoy et al., 2014; Wang et al., 2016). Here, GBP2 is linked to colorectal cancer.