We found that GBP1, 2, 3, 4 are closely related to immune-related signaling pathways, such as intestinal immune network for IgA production, primary immunodeficiency, B/T cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, etc., which was consistent with the association between GBP1, 2, 3, 4 and immune cell infiltration that we explored above. Here, GBP1 is linked to inborn error of immunity.