We found that GBP1, 2, 3, 4 are closely related to immune-related signaling pathways, such as intestinal immune network for IgA production, primary immunodeficiency, B/T cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, etc., which was consistent with the association between GBP1, 2, 3, 4 and immune cell infiltration that we explored above. The gene discussed is CD79A; the disease is inborn error of immunity.