Patients with atopic dermatitis show increased expression of Klrg1 and the interaction of activated ILC2s with E-cadherin results in a down regulation of GATA-3, IL-5, IL-13, amphiregulin and reduced ILC2 proliferation; suggesting a negative regulatory role for Klrg1 in skin ILC2s (16). The gene discussed is IL5; the disease is atopic eczema.