Plumbagin was shown to protect mice from lethal endotoxemia and polymicrobial sepsis induced by cecal ligation and puncture (CLP) by inhibiting the NADPH oxidase 4 (NOX4)/PKM2-dependent immunometabolism pathway, which inhibits LPS-induced PKM2 expression, lactate production and subsequent proinflammatory cytokine (IL-1β and HMGB1) release in macrophages (192). This evidence concerns the gene NOX4 and Sepsis.