The expression of B2m, Ctsl, Calr, and Pdia3 suggests efficient antigen processing and presentation process, and the upregulation of Rac1, and Cd14 indicats the involvement of TLR2 and TLR4, which are essential for Th1/Th17 responses elicited by wPVs or bacterial infection (Higgins et al., 2006; Reynolds et al., 2010; Brummelman et al., 2015). The gene discussed is TLR4; the disease is bacterial infectious disease.