The receptor/ligand pairs of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF) including OX40/OX40L not only have a prominent role as controllers of T lymphocyte activation and survival, but are also associated with exacerbating effects in inflammatory processes and autoimmunity (Webb et al., 2016). The gene discussed is TNFRSF4; the disease is Autoimmunity.