SNCA and Parkinson disease: The repeated low-dose reserpine protocol has been used as a model of progressive parkinsonism, showing phenomenological (progressive motor alterations) and construct (reduced dopaminergic parameters, increased oxidative stress, and augmented alpha-synuclein expression) similarities with PD (Fernandes et al., 2012; Santos et al., 2013; Leão et al., 2015, 2017, 2021; Ikram and Haleem, 2019).