DDIT3 and amyotrophic lateral sclerosis: Moreover, overexpression of TDP-35 and -25 CTFs (both consistently detected in the frontal and temporal lobes of people with ALS and FTLD; Berning and Walker, 2019) produced an increase in levels of p-eIF2α and CHOP expression as well as cleaved caspase-12 (Wang et al., 2015a), a major ER stress-induced pro-apoptotic protein.