TARDBP and amyotrophic lateral sclerosis: Phosphorylation, ubiquitination, and aberrant cleavage are the most significant post-translational modifications found in TDP-43 protein inclusions and are believed to associate with the pathogenic alterations observed in ALS and FTLD patients (Neumann et al., 2006; Hasegawa et al., 2008; Igaz et al., 2008; Kametani et al., 2016; Buratti, 2018).