HNRNPH1 and amyotrophic lateral sclerosis: By using reciprocal pull-downs and a transgenic model, the authors validated a 28-member RNA-binding protein complex associated with amyotrophic lateral sclerosis, which includes hnRNPH1 (Pourhaghighi et al., 2020), in line with a study reporting on the role of hnRNPH-F sequestered together with other hnRNPs in toxic RNA foci in the spinal cord of amyotrophic sclerosis patients (Cooper-Knock et al., 2015).