Moreover, experimentally determined evidence in the literature connects both MAGOHB, core component of the exon junction complex (EJC) through its peripheral proteins and the core proteins of the uridine-rich small ribonucleoproteins (snRNPs) to the neural-specific microexon splicing program governed by the serine arginine repetitive matrix 4 (SRRM4) protein, which reduced expression in Ep300 and Crebbp-depleted mouse neurons, has been linked to cognitive dysfunction and autism (Gonatopoulos-Pournatzis et al., 2018). This evidence concerns the gene SRRM4 and autism.