Detailed presentation of different INF-γ + 874 T/A (rs2430561) genotype showing metastasis was presented in (Table 6). When concerning different predictive models, the reference one with good prognosis luminal A model, (ER+ve PR+ve Her2-ve) model we found (7/64 metastasis cases, 11%) one case in AA genotype of INF-γ + 874 T/A (rs2430561) SNP with bone metastasis, 5 cases in AT genotype (2 with lung and 3 with bone) metastasis and one cases in TT genotype (bone & lung metastasis). Here, ESR1 is linked to bone metastasis.