When analyzing different prognostic model a significant association in INF-γ + 874 T/A SNP with the poor prognostic model of luminal B model, (ER+ve PR+ve Her2+ve) in the codominant model (AA vs. TT, P = 0.03) as well as recessive model (TT versus AA + AT P = 0.02) when compared to the good prognostic hormonal status luminal A model, (ER+ve PR+ve Her2-ve). This again confirms the association of TT genotype with the aggressiveness type of BC. This evidence concerns the gene PGR and breast cancer.