CD8A and neoplasm: Within the adaptive immune response, T helper1 (Th1) CD4 + T cells and CD8 + cytotoxic T cells are coexisting in the polarized immune response (Mah and Cooper, 2016, Negishi et al., 2017). First INF-γ was known exclusively as antitumor, that it has anti-proliferative effects on tumor cells by different actions like, promote myeloid cell activation, antigen presenting cells activation and induce directed cellular migration.