In breast cancer, the levels of cytokine in serum may be correlated to specific immune cell types at the tumor microenvironment which experienced the important of measuring serum cytokine levels (Jabeen et al., 2019, Kaur et al., 2018, Yaghoobi et al., 2018). The production of INF is correlated to the functional SNPs INF-γ T + 874A, presenting the T allele contributing to the high INF production, and the A allele responsible for the low INF production. This evidence concerns the gene CBLIF and breast cancer.