Moreover, CDK2-deficient Tregs are more suppressive and ameliorate colitis in an in vivo mouse model of IBD; [50] this is primarily because the N-terminal amino acid sequence of Foxp3, which contains four CDK substrate motifs and is phosphorylated by CDK2, leading to Foxp3 instability [13]. This evidence concerns the gene FOXP3 and inflammatory bowel disease.