To determine whether increased numbers of Tregs in IBD are related to high intestinal CD98 expression, we stained intestinal tissue sections of 26 patients with IBD, including 20 patients with ulcerative colitis and 6 patients with Crohn’s disease, for CD98, CD147, CD4, Foxp3, IFNγ, and IL-17 using multicolor immunofluorescence labeling. This evidence concerns the gene SLC3A2 and Crohn disease.