ALKBH5 and acute myeloid leukemia: For example, Wang et al. demonstrated that histone demethylase KDM4C reduced the H3K9me3 (trimethylation of lysine 9 on histone H3) level and increased the chromatin accessibility of ALKBH5 locus, that in turn promoted the transcription of ALKBH5 in AML cells [26].