Furthermore, we established doxycycline (Dox)-inducible ALKBH5 conditional KD MM cell lines (shA5_Tet-on), and conditional depletion of ALKBH5 (Fig. S2I) significantly inhibited MM cell proliferation (Fig. 2U) and colony formation (Fig. 2V, W). This evidence concerns the gene ALKBH5 and Miyoshi myopathy.