WNK2 and cancer: Several of these differentially expressed genes were enriched in apoptosis, cell cycle, pathways in cancer, nuclear factor-kappa B (NF-κB) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, and phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis (Fig. 5A), which was consistent with the phenotype alterations caused by ALKBH5 KD and GSEA of patient datasets.