CAMK2A in association with Gap junction protein alpha 1 (GJA1) phosphorylated at Ser 325 and Ser 314, plays an important role in metastatic invasion, promoting gap junction assembly between glioma cells and surrounding astrocytes [90] as well as increasing synaptic transmission through the phosphorylation of Synapsin-1 (SYN1) at Ser 605 by CAMK2A [89]. This evidence concerns the gene GJA1 and glioma.