To clarify the relationship between hyperglycemia and OA, as well as the role of FLSs in the progression of OA, we collected human synovium from OA patients with or without DM, generated a rat model of DM-related OA, and prepared high glucose-stimulated rat FLS cultures in vitro to explore the role of FLSs in DM-related OA and the mechanism, involving GLUT1 and AGEs. The gene discussed is SLC2A1; the disease is Hyperglycemia.