Its expression is upregulated in many acute and chronic inflammatory diseases such as sepsis [19], passive cutaneous anaphylaxis and atopic dermatitis [9], Alzheimer’s disease [20, 21], dementia [22], schizophrenia [16, 23], diabetic nephropathy [24, 25], and cancer [15, 26, 27], suggesting that swiprosin-1 played a role in inflammation processes of many diseases. Here, EFHD2 is linked to Sepsis.