To investigate whether swiprosin-1 expression in macrophages contributed to the progression of atherosclerosis [34], bone marrow transplantation from swiprosin-1−/− mice as a donor to ApoE−/− as a recipient and swiprosin-1+/+ mice as a donor to ApoE−/− as a recipient were performed and then fed with HCD for 4 months. This evidence concerns the gene APOE and atherosclerosis.