We then proved that circ-SIRT1 and its homologous mouse circ-Sirt1 were low-expressed in Ang II- or ISO-induced CH cell model in vitro and in Ang II infusion-induced CH mice model in vivo, supporting the link between circ-SIRT1 (and circ-Sirt1) and CH. The gene discussed is AGT; the disease is cyclic hematopoiesis.