MAPT and Mental deterioration: Previous research has validated MBI as a preclinical dementia syndrome and associated with amyloid positivity, before tau and neurodegeneration in older adults with normal cognition, which was consistent with our findings that MBI was a cause to the cognitive decline mainly via β-amyloid, also in advance of tau or neurodegeneration biomarkers, irrespective of the presence or absence of subjective cognitive complaints [13].