LINK-A (long intergenic noncoding RNA for kinase activation) was highly upregulated in triple-negative breast cancer (TNBC) and functioned in facilitating BRK kinase activation which promoted HIF-1α Tyr565 phosphorylation and stabilized HIF-1α by interfering with Pro564 hydroxylation to enhance HIF-1α-p300 interaction and HIF-1α transcriptional activity under normoxic condition [33]. The gene discussed is EP300; the disease is triple-negative breast carcinoma.