They both use ACE2 as the host receptor12,13 and display similar ACE2 binding motifs in the S protein.14,15 The distribution and abundance of ACE2 in organs is related to the clinical symptoms of COVID-19.16 ACE2 is broadly expressed in heart, kidneys, testes, lungs, liver, intestine, and brain. This evidence concerns the gene ACE2 and COVID-19.