Using logistic regression analysis, IL-1RA was significantly related to incident MetS in the PIVUS study during 5 years follow-up (number of events = 109) when adjusted for smoking, exercise habits, education, and energy and alcohol intake (HR 1.76 for a 1 SD change (95% CI 1.38, 2.24), p = 4.3*10–6, see Fig. 3). The gene discussed is IL1RN; the disease is metabolic syndrome.