EPB41L4A and cancer: EPB41L4A-AS1 was first reported as a protein-coding gene named TIGA1 related to cell proliferation [9]; later studies demonstrated that EPB41L4A-AS1 mainly functioned as a lncRNA associated with cell metabolism and immune response [7, 10, 11], and its downregulation in cancer cells induced glutamine dependency and promoted glycolysis [7].