Twelve of the top 15 genes across all PitNETs were mitochondrially encoded enzymes and the three other genes encoded for two of the pituitary hormones GH and PRL, and the G protein GNAS, mutated in up to 50% of sporadic somatotroph tumors [14, 20, 41]. Here, GH1 is linked to growth hormone-producing pituitary gland neoplasm.