Interestingly, most of these genes have been associated with malignancies in different tissues and organs, either as tumor promoting genes (ERRFI1, FKBP10, TAC4, ASAP2, CACNA2D, RASA4, SSX2IP, ELN, KRT8), tumor suppressors (SLC44A3, SERPINF1, ZBTB49, RALGAPA2, CIB2, USP53), or both (SLC39A8). This evidence concerns the gene SERPINF1 and neoplasm.