USP53 and neoplasm: Interestingly, most of these genes have been associated with malignancies in different tissues and organs, either as tumor promoting genes (ERRFI1, FKBP10, TAC4, ASAP2, CACNA2D, RASA4, SSX2IP, ELN, KRT8), tumor suppressors (SLC44A3, SERPINF1, ZBTB49, RALGAPA2, CIB2, USP53), or both (SLC39A8).