IKBIP, a novel marker of epithelial-mesenchymal transition (EMT) predicting poor prognosis in gliomas [54], was found to be expressed in blood vessels of all PitNETs and showed strong cytoplasmic positivity in PIT1 tumor cells and was essentially negative in tumor cells from SF1 and TPIT tumors (Fig. 3c). This evidence concerns the gene POU1F1 and central nervous system cancer.