Interestingly, most of these genes have been associated with malignancies in different tissues and organs, either as tumor promoting genes (ERRFI1, FKBP10, TAC4, ASAP2, CACNA2D, RASA4, SSX2IP, ELN, KRT8), tumor suppressors (SLC44A3, SERPINF1, ZBTB49, RALGAPA2, CIB2, USP53), or both (SLC39A8). The gene discussed is RALGAPA2; the disease is neoplasm.