PLOD1 and neoplasm: PitNET of any histological type may cause symptoms due to hormone hypersecretion, such as acromegaly related to GH hypersecretion, Cushing disease related to ACTH hypersecretion, symptoms related to hyperprolactinaemia, TSH or, very rarely, FSH/LH hypersecretion, or behave as a silent tumor, without laboratory or clinical signs of hormone hypersecretion.