Analysis of the promoters of the genes activated by the expression of these four IBD genes (Additional file 1: Table S6) found an enrichment of binding sites for STAT1::STAT2 and for members of the IRF family in three of these (IFIH1, SBNO2, and NFKB1) and of NFkB sites (REL and RELA) in two (NFKB1 and NOD2). This evidence concerns the gene REL and inflammatory bowel disease.