While the results presented herein make a strong case for multiple IBD genes being involved in the Type I IFN response, it is possible that they may also act on Type III signaling as the HITS for these genes were also enriched for gene annotations “Type III interferon signaling” and/or “response to interferon-gamma,” although to a lesser extent (Additional file 3: Cluster 1 data). Here, IFNG is linked to inflammatory bowel disease.