As can be seen in Fig. 3D and Additional file 2: Fig.S5A, these IBD-associated variants had an impact on the transcriptome that was quantitatively (Additional file 1: Table S9), but not qualitatively different as compared to the wildtype ORF, either from a global perspective (Fig. 3D) or when evaluating the top 10 HITS in the cells expressing the IFIH1 ORF (Additional file 2: Fig.S5A). Here, IFIH1 is linked to inflammatory bowel disease.