As can be seen in Fig. 2, this analysis revealed two large distinct gene clusters: Cluster 1 includes multiple known IBD causal genes including IFIH1, SBNO2, NFKB1, and NOD2, with several candidate genes connecting to them, while Cluster 2 has multiple candidate genes connecting to the IBD causal gene KSR1. This evidence concerns the gene KSR1 and inflammatory bowel disease.