In two separate mouse models, one group found that that upregulation of S100A8/A9 may be protective against anxiety-like behavior following sepsis [101], while another group found that pharmacological inhibition of S100A9 with paquinimod effectively ameliorated depressive behaviors in a model of chronic unpredictable mild stress (CUMS) [31]. This evidence concerns the gene IGKV1D-22 and Anxiety.