Finally, we did not analyze the time of MACE incidence and thereby we could not perform Kaplan Meier analysis which could have added a time dependent pattern of RBP-4.On the other hand, we grouped PAD patients based on MACE, and thereby we focused entirely on the prognostic value of biomarkers on a relatively short-time follow-up period. The gene discussed is RBP4; the disease is peripheral arterial disease.