Using Spearmen r ≥ 0.3 or r ≤ − 0.3 and p < 0.001 as a cut-off, we showed that CD40 is moderately co-expressed with CD40LG in the normal tissues (r = 0.44) and in the tumor microenvironment (TME, r = 0.37). This evidence concerns the gene CD40 and neoplasm.