Moreover, although the increased FN1 expression which followed with the activite of p-Akt1 had observed in this study, however, the opposite role of p-Akt1 on regulating FN1 expression also reported in breast cancer cells [41], the interaction between FN1 and p-Akt1 may be have a more complex manner. The gene discussed is FN1; the disease is breast carcinoma.