Conversely, the protein level of MMP2/MMP9 and cell motility were recovered when FN1 expression was rescued by transient transfection of an Akt1 recombinant plasmid in HK2-knockdown cells, suggesting that there is probably an HK2-Akt1-FN1-MMP2/MMP9 signaling axis promoting cell motility in cervical cancer cells. The gene discussed is FN1; the disease is cervical carcinoma.