Interestingly, although a significantly increased protein level of Akt1/p-Akt1 was observed in HK2-overexpressing cervical cancer cells, when such elevated Akt1/p-Akt1 expression was inhibited by using MK2206, the protein level of HK2 was also significantly diminished in HK2-overexpressing cells. The gene discussed is AKT1; the disease is cervical cancer.