CDH2 and neoplasm: For example, the transcription levels of epithelial markers (CDH1 and EpCAM) increased significantly, while those of the mesenchymal markers (CDH2 and vimentin) decreased after HD treatment at various concentrations, indicating that the LLPS microenvironment formed by the LCD structures of KMT2D could effectively alter the EMT activity of tumor cells (Fig. 6d).