Regarding NE tumors, the SCLC-A subtype overexpressed Delta-like protein 3 (DLL3), a NOTCH signaling inhibitor (Saunders et al., 2015), and NOTCH activation in the SCLC-A subtype decreased tumorigenesis (George et al., 2015; Lim et al., 2017). This evidence concerns the gene DLL3 and small cell lung carcinoma.