Non-NE SCLC has been subdivided into SCLC-Y and SCLC-P based on elevated expression of the transcription factors YAP1, involved in HIPPO signaling, and POU2F3, which signifies tuft cell rather than pulmonary NE cell origin, respectively (Rudin et al., 2019 and references therein). The gene discussed is POU2F3; the disease is small cell lung carcinoma.