SCLC tumors are characterized by deletions or loss-of-function mutations of TP53 (George et al., 2015; Peifer et al., 2012; Rudin et al., 2012) and TP53 inactivation impairs upregulation of BH3-only pro-apoptotic proteins (Villunger et al., 2003). Here, TP53 is linked to small cell lung carcinoma.