Given the role of TIAM1-RAC1 signaling in promoting tumor initiation and growth (Maltas et al., 2020) and our above findings that TIAM1 expression positively correlates with NE score, we hypothesized that TIAM1-RAC1 signaling might be important for the viability of NE SCLC cells. Here, TIAM1 is linked to small cell lung carcinoma.