To determine if resting dysfunctional (CTVlo) TCRTg101in vitro with cytokine support could restore their ability to survive and expand, CTVhi and CTVlo TCRTg101 isolated from livers of leukemia-bearing animals were cultured with interleukin (IL)-2, IL-7, and IL-15 for 5 days, at which point, CTVhi TCRTg101 had expanded 1.5-fold; conversely, very few CTVlo TCRTg101 survived (Figures S5B and S5C). Here, IL2 is linked to leukemia.