CD8A and leukemia: We previously demonstrated in leukemia-bearing mice that cross-presentation of a leukemia-specific antigen by splenic CD8α+ type 1 conventional dendritic cells (cDC1s) induced the deletion of a CD8+ T cell population expressing a high-affinity T cell receptor (TCR; referred to as TCR2C) (Kline et al., 2018; Zhang et al., 2013).