CD8A and leukemia: In order to elucidate the extent to which deletion was a fate shared by other leukemia-specific CD8+ T cells, we generated a TCR transgenic mouse strain (referred to as Tg101) harboring a clonal CD8+ T cell population specific for a naturally expressed, major histocompatibility complex (MHC) class I-restricted antigen on murine C1498 leukemia cells.