CD8A and leukemia: Interestingly, however, even in mice with advanced leukemia, exhausted TCRTg101 largely retained proliferative capability, indicating that the regulation of cell-cycle progression and effector function are uncoupled until very late stages of TCRTg101 dysfunction, which has been previously demonstrated in exhausted CD8+ T cells in settings of cancer and chronic viral infection (Schietinger et al., 2016; Wherry, 2011).