Twenty two candidates represent the most likely new, fully penetrant, Mendelian disease genes (Table S8 in the Supplementary Appendix and ClinVar accession numbers SCV001759972 - SCV001760540) with three recently independently confirmed diagnoses: UBAP1 in hereditary spastic paraplegia,27FOXJ1 in non-CF bronchiectasis,28 and SORD in Charcot-Marie Tooth disease.29 Diagnostic reports were issued for three probands with these genes (Figure 1) and we are investigating others in GeneMatcher and by functional validation studies in model organisms. The gene discussed is SORD; the disease is hereditary spastic paraplegia.