Moreover, Nrp‐1highCD4+CD25+ Tregs revealed primary negative immunoregulatory activity in reaction to sepsis, while administration of a recombinant version of Nrp‐1 polyclonal antibody markedly lowered the demethylation of Foxp3‐TSDR in a dose‐dependent manner under LPS stimulation.15 Here, FOXP3 is linked to Sepsis.