Moreover, PPAR‐γ activation is known to enhance angiogenesis and the migration of human brain microvascular endothelial cells through the formation of the fibroblast growth factor‐21/fibroblast growth factor receptor‐1/β‐Klotho complex, and improve the ability of vascular recanalization and nerve repair after stroke (W. Huang et al., 2019). This evidence concerns the gene KLB and stroke disorder.