Chitinase 3 like1 (CHI3L1), an 18‐glycosyl hydrolase (GH 18) gene family member, has properties of cytokines and growth factors and is secreted by macrophages, neutrophils, synoviocytes, chondrocytes, cancer cells, epithelial cells, and smooth muscle cells [1, 2, 3]. The gene discussed is CHI3L1; the disease is cancer.