Increased expression and serum levels of CHI3L1 have been associated with nonmalignant diseases, such as diabetes, Alzheimer's disease, and asthma, as well as with many human neoplasias, including breast, colon, prostate, ovarian, brain, thyroid, bladder, stomach, endometrial, esophageal, pancreatic, head and neck, lung, and liver cancers [1, 4, 5, 6]. The gene discussed is CHI3L1; the disease is neoplasm.