He et al. [10] reported that CHI3L1 binds to IL‐13Rα2 and activates IL‐13Rα2‐dependent MAPK, AKT, and Wnt/β‐catenin signaling pathways, thereby regulating apoptosis, inflammasome activation, and melanoma metastasis. This evidence concerns the gene CHI3L1 and melanoma.