The activities of SP‐1 and STAT3 induced by NF‐κB, USF1, and IL‐6 were not significantly affected by K284 treatment, but lipopolysaccharide‐ and TNF‐α‐induced SP‐1, STAT3, and AP‐1 were significantly decreased by K284 treatment in A549 lung cancer cells (Fig. S8). This evidence concerns the gene JUN and lung cancer.