BACE1 and Alzheimer disease: With regards to lncRNAs in AD pathology, BACE1-AS, a natural antisense transcript (NAT), which is a transcript that is endogenously transcribed from β-amyloid precursor protein cleaving enzyme 1 mRNA sequence has been shown to trigger production and aggregation of Aβ through BACE1 activity, leading to detrimental effects [68].