Investigation of the mechanisms and consequences of TLR2 signaling have primarily focused on pathogen-specific induction of type I IFNs (Barbalat et al., 2009; Dietrich et al., 2010; Musilova et al., 2019; Stack et al., 2014) and TNF (Ip et al., 2010; Brandt et al., 2013), largely in response to S. aureus exposure or viral infection. Here, TNF is linked to viral infectious disease.