There is strong evidence in animal models that agonizing Tie2 with Ang‐1 mimetics improves the severity of lung injury in animal models following endotoxin (David et al., 2011; Huang et al., 2008; McCarter et al., 2007) and pneumococcal pneumonia (Gutbier et al., 2017). This evidence concerns the gene TEK and pneumococcal pneumonia.