Furthermore, Tie‐2 agonism by Ang‐1‐expressing adenovirus or the Ang‐1 peptide mimetic vasculotide has been shown to improve experimental lung injury caused by endotoxin (David et al., 2011; Huang et al., 2008), hemorrhagic shock (Trieu et al., 2018), cardiopulmonary bypass (Dekker et al., 2018), and pneumococcal pneumonia (Gutbier et al., 2017). This evidence concerns the gene TEK and pneumococcal pneumonia.