ANGPT1 and pneumococcal pneumonia: Furthermore, Tie‐2 agonism by Ang‐1‐expressing adenovirus or the Ang‐1 peptide mimetic vasculotide has been shown to improve experimental lung injury caused by endotoxin (David et al., 2011; Huang et al., 2008), hemorrhagic shock (Trieu et al., 2018), cardiopulmonary bypass (Dekker et al., 2018), and pneumococcal pneumonia (Gutbier et al., 2017).