In light of prior work demonstrating the prognostic significance of the Ang‐2 to Ang‐1 ratio in patients with ARDS (Ong et al., 2010) and a number of studies suggesting therapeutic benefit from Ang‐1 agonism (Gutbier et al., 2017; Huang et al., 2008), the increase in Ang‐1 signaling induced by L1‐7 may be an important mechanism of reduced pulmonary edema, particularly given that reduced free Ang‐2 levels likely facilitate Tie2 binding opportunities for Ang‐1. The gene discussed is ANGPT2; the disease is acute respiratory distress syndrome.