Neutrophilia at COVID-19 diagnosis is a risk factor for critical disease2 and neutrophil extracellular neutrophil traps (NETs) are a key pathogenic factor in COVID-19.3 Furthermore, NETs contribute to the cytokine storm by promoting IL-1β secretion in macrophages via the inflammasome activation, which induces IL-6 production4 and favors a hypercoagulability state.5 This evidence concerns the gene IL1B and COVID-19.