DNAJB6 works at the level of formation of polyQ oligomers independent of the context flanking the polyQ region (Hageman et al., 2010; Kuiper et al., 2017; Mansson et al., 2018), and thus its use can be extrapolated to other polyQ disorders such as spinocerebellar ataxia, spinal and bulbar muscular atrophy, and dentatorubropallidoluysian atrophy (Orr and Zoghbi, 2007). The gene discussed is DNAJB6; the disease is cerebellar ataxia.