Biomarkers such as molecules involved in autophagic machinery or Nox2 activation may help to explain pathological processes involved in TAA development and expansion, thereby opening up novel potential therapeutic strategies in the setting of aneurysmatic pathology.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Formation of aortic aneurysmal disease is multifactorial. Here, CYBB is linked to aortic aneurysm.