Tumors belonging to the proliferation group are highly heterogeneous, enriched in signaling pathways (e.g., transforming growth factor-β, phosphatidylinositol 3-kinase, and protein kinase B (PI3K-Akt), insulin-like growth factor, mechanistic target of rapamycin (mTOR), with stem-cell signaling Notch) and with very high gene expression patterns that result in tumor recurrence and shorter patient survival. This evidence concerns the gene AKT1 and neoplasm.