In a large multinational cohort of HCC patients undergoing TACE, the hepatic arterial prognosis score (HAP, diameter of the largest HCC, serum AFP, albumin, and bilirubin) validation, the prognostic value of albumin-bilirubin (ALBI) score, and the impact of macrovascular invasion on survival were studied, followed by an expanded analysis. The gene discussed is ALB; the disease is hepatocellular carcinoma.