Single nucleotide polymorphisms (SNPs) of patatin-like phospholipase domain-containing protein-3 (PNPLA3, rs738409), transmembrane 6 superfamily member-2 (TM6SF2, rs58542926), and hydroxysteroid 17-beta-dehydrogenase-13 (HSD17B13, rs72613567) were found to modulate the risk of chronic liver disease and HCC development, mainly in patients with alcohol-related and non-alcoholic fatty liver disease [37-38]. This evidence concerns the gene TM6SF2 and hepatocellular carcinoma.