CD274 and neoplasm: A study investigating the combination of the anti-PD-L1 antibody atezolizumab with the anti-VEGF antibody bevacizumab (IMbrave 150 Study Group) tested the hypothesis that bevacizumab would increase the activation of CD8+ T cells by reversing the immunosuppressive effects of VEGF, thereby inducing immunosuppressive cells such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells towards cytotoxicity against tumor cells.