On the other hand, the non-proliferating HCC most often has retained hepatocyte-like features, subset activation of the canonical Wnt, epidermal growth factor signaling, and activation of inflammation pathways, such as nuclear factor-kB and interleukin (IL)-6; mutations in the CTNNB1 gene tend to be less-aggressive, well-differentiated tumors with low AFP secretion and good prognosis. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.