INS and Insulin resistance: In a recent meta-analysis by Simental-Mendía et al., fibrate therapy significantly reduced fasting plasma glucose (-0.28 mmol/L), insulin levels (-3.87 pmol/L), and insulin resistance [Homeostasis Model of Assessment for Insulin Resistance (HOMA-IR) -1.09], with no effect on glycated hemoglobin (HbA1c) [121].