The IL-1B (-511) and IL-1RN (VNTR) polymorphisms have been reported to be related to the pathogenesis of T2DM (Ehses et al., 2009; Masters et al., 2010), and many case-control studies have illustrated the association of IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk. The gene discussed is IL1RN; the disease is type 2 diabetes mellitus.