Several results suggest that there is no relationship between them (Borilova Linhartova et al., 2019; Muktabhant et al., 2013), whereas Achyut et al., (2007) showed that both the IL-1B (-511) and IL-1RN (VNTR) polymorphisms were associated with susceptibility to T2DM as well as complications, and he indicated that T2 (IL-1β −511T/IL-1RN*2) haplotype was associated with a roughly twofold increased risk of T2DM. The gene discussed is IL1RN; the disease is type 2 diabetes mellitus.