The results of the pooled analysis suggest that the IL-1B (-511) polymorphism is not significantly associated with T2DM risk in all study subjects under the dominant model (OR = 0.84, 95% CI [0.57–1.25], Phet = 0.001, Pz = 0.395) (Table 3 and Fig. 2A), recessive model (OR = 0.89, 95% CI [0.61–1.31], Phet < 0.001, Pz = 0.561) (Table 3), and homozygous model (OR = 0.82, 95% CI [0.48–1.39], Phet < 0.001, Pz = 0.451) (Table 3). This evidence concerns the gene IL1B and type 2 diabetes mellitus.