Increasing evidence has shown that metaflammation plays a vital role in the development of T2DM and its cardiovascular complications (Hotamisligil, 2017) and pro-inflammatory cytokines, especially interleukin-1β (IL-1β), play a key role in this process (Dinarello, Donath & Mandrup-Poulsen, 2010; Fève & Bastard, 2009; Sathyapalan & Atkin, 2011). The gene discussed is IL1B; the disease is type 2 diabetes mellitus.