Jang et al. (2012) reported that overexpression of miR-708-5p increased proliferation and invasion of lung cancer cells by experimental methods, and further identified a valuable link that miR-708-5p may directly downregulate TMEM88 that weakened Wnt activity to promote lung cancer progression. In the contrary, the work of Monteleone & Lutz (2020) demonstrated that miR-708-5P exerted an inhibitory effect on lung carcinogenesis by suppressing Prostaglandin E2 (PGE2) signaling. This evidence concerns the gene TMEM88 and lung cancer.